Programme no. 505-SY
Personalized medicine meets general practice - a SWOT analysis
Linn Getz*1, Johann A Sigurdsson2, Henrik Vogt*3, Lotte Hvas*4
1General Practice Research Unit, Department of Public Health and General Practice,Norwegian University of Science and Technology,Trondheim,Norway, 2Department of Family Medicine,University of Iceland,Reykjavik,Iceland, 3General Practice Research Unit, Department of Public Health and General Practice,Norwegian University of Science and Technology,Trondheim,Norway, 4Research Unit for General Practice,University of Copenhagen,Copenhagen,Denmark
* = Presenting author
Objectives: To explore the topic ‘Personalized medicine” and how it might influence general practice. This symposium is planned to supplement Linn Getz’ keynote lecture about two emerging ‘person’ concepts in medicine; ‘high tech’ Personalized medicine versus ‘humanistic’ Person-centered medicine.
From the start, ‘Personalized medicine’ referred to genome-based tailoring of medical interventions (e.g. choice of cancer therapy according to gene variants). To an increasing extent, however, Personalized medicine refers to lifelong monitoring of billions of datapoints pertaining to numerous “-omics” levels (genomics, transcriptomics, proteomics, metabolomics, etc.). On the basis of mathematical algorithms and computer networks, the plan is to “quantify health” and monitor susceptibilities with the aim to intervene before disease becomes manifest. The “multi –omics” version of Personalized medicine is often referred to as “Systems 4P medicine.” 4P is promoted by strong rhetoric familiar to GPs: The 4 Ps stand for Predictive, Preventive, Personalized and Participatory, followed by “holistic” and “integrative.” We ask: To what extent can 4P ctually deliver according to its promises? Can it be reconciled with humanistic person-centered medicine?
The symposium is rooted in a ph.d. project at the GP Research Unit in Trondheim titled “System medicine as a theoretical foundation for general practice – a critical analysis,” with Henrik Vogt as the ph.d. candidate. We invite you to share both our fascination and concerns in relation to 4P medicine, with the aim to develop an informed, constructive-critical attitude within the GP community.
We will cover the Strenghts, Weaknesses, Possibilities and Threats (SWOT) associated with 4P Systems Medicine:
-Systems thinking is not a new idea for GPs: a historical overview.
-From EBM to 4P medicine and 'virtual patients': What about the GP?
-4P medicine: Liberation or medicalization? Systems medicine introduces a more comprehensive and dynamic physiological view of human health and disease than contemporary biomedicine. Still, we worry: Will it make human life and society become even more medicalized, and the healthcare system even more unequal (the inverse care law) in an era of “-omics” and big data?
-In the near future, “digitalized patients” will carry their personal laboratories (= sensors and smartphones) with them. Will the digitalized patient be an empowered citizen, an exploited consumer, or perhaps both?
Method: Presentations and discussion
Other considerations: This symposium is planned to complement the symposium; Person Centred Medicine - a humanistic approach to the clinical foundation of Family Medicine